Ion channels as therapeutic targets for viral infections: further discoveries and future perspectives

FW Charlton, HM Pearson, S Hover, JD Lippiat… - Viruses, 2020 - mdpi.com
Ion channels play key roles in almost all facets of cellular physiology and have emerged as
key host cell factors for a multitude of viral infections. A catalogue of ion channel-blocking …

G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes

G Giraud, M Rodà, P Huchon, M Michelet… - Nucleic Acids …, 2024 - academic.oup.com
Phase separation regulates fundamental processes in gene expression and is mediated by
the local concentration of proteins and nucleic acids, as well as nucleic acid secondary …

Co-Transcriptional Regulation of HBV Replication: RNA Quality Also Matters

G Giraud, K El Achi, F Zoulim, B Testoni - Viruses, 2024 - mdpi.com
Chronic hepatitis B (CHB) virus infection is a major public health burden and the leading
cause of hepatocellular carcinoma. Despite the efficacy of current treatments, hepatitis B …

G-quadruplexes in the evolution of hepatitis B virus

V Brázda, M Dobrovolná, N Bohálová… - Nucleic Acids …, 2023 - academic.oup.com
Hepatitis B virus (HBV) is one of the most dangerous human pathogenic viruses found in all
corners of the world. Recent sequencing of ancient HBV viruses revealed that these viruses …

Demonstration of a Ribozyme in Epsilon Domain of Hepatitis B Virus RNA

D Chakraborty, S Ghosh - Ribozymes: Methods and Protocols, 2021 - Springer
The epsilon domain of Hepatitis B virus plays a crucial role in encapsidation of viral
pregenomic RNA and its partial NMR structure has been determined. However, we recently …

Composition for Inhibiting Replication of Hepatitis B Virus

T Munakata, M Kohara, T Sanada - US Patent App. 17/294,171, 2022 - Google Patents
The present invention provides a pharmaceutical composi tion for treating hepatitis B. The
present invention provides a composition for inhibiting the replication of hepatitis B virus and …

A new class of ribozyme from hepatitis B virus.

CS Lim, C Brown - The FEBS Journal, 2017 - europepmc.org
In this issue, Chakraborty and Ghosh present initial in vitro data indicating a 53-base part of
the hepatitis B virus (HBV) epsilon region is a ribozyme with unusual properties. Self …