The complement system, an essential part of the innate immune system, is composed of a
group of secreted and membrane proteins that collectively participate in maintaining the …

Increased awareness of cognitive and behavioural change in amyotrophic lateral sclerosis
has been driven by various clinic-based and population-based studies. A frontotemporal …

Abstract Adenosine kinase (ADK; EC 2.7. 1.20) is an evolutionarily conserved
phosphotransferase that converts the purine ribonucleoside adenosine into 5′-adenosine …

Background: The prognostic implications of cognitive impairment in amyotrophic lateral
sclerosis (ALS) are not established. Objectives: To investigate the survival effect of the …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …

Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease,
and only modest disease-modifying strategies have been established to date. Numerous …

Introduction: A spectrum of non-motor manifestations in amyotrophic lateral sclerosis (ALS)
patients has been increasingly recognized, with cognitive and behavioral impairments the …

Comorbidities in Neurology represent a major conceptual and therapeutic challenge. For
example, temporal lobe epilepsy (TLE) is a syndrome comprised of epileptic seizures and …

Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a
neurodegenerative disease in which motor neuron death is induced, a wide range of …

Huntington's disease is classically described as a neurodegenerative disorder of monogenic
aetiology. The disease is characterized by an abnormal polyglutamine expansion in the …