Current progress in understanding schizophrenia using genomics and pluripotent stem cells: A meta-analytical overview

A Choudhary, D Peles, R Nayak, L Mizrahi… - Schizophrenia Research, 2024 - Elsevier
Schizophrenia (SCZ) is a complex, heritable and polygenic neuropsychiatric disease, which
disables the patients as well as decreases their life expectancy and quality of life. Common …

[HTML][HTML] NMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease Models

R Tumdam, Y Hussein, T Garin-Shkolnik… - International Journal of …, 2024 - mdpi.com
N-methyl-D-aspartate receptors (NMDARs) are critical components of the mammalian
central nervous system, involved in synaptic transmission, plasticity, and neurodevelopment …

Uncovering convergence and divergence between autism and schizophrenia using genomic tools and patients' neurons

E Romanovsky, A Choudhary, D Peles… - Molecular …, 2024 - nature.com
Autism spectrum disorders (ASDs) are highly heritable and result in abnormal repetitive
behaviors and impairment in communication and cognitive skills. Previous studies have …

Altered Expression of PDE4 Genes in Schizophrenia: Insights from a Brain and Blood Sample Meta-Analysis and iPSC-Derived Neurons

N Burrack, A Yitzhaky, L Mizrahi, M Wang, S Stern… - Genes, 2024 - mdpi.com
Schizophrenia symptomatology includes negative symptoms and cognitive impairment.
Several studies have linked schizophrenia with the PDE4 family of enzymes due to their …

[HTML][HTML] Focusing on the tetra-partite synapse in Parkinson's disease research using human patient-derived neurons

D Cordeiro, T Stern, S Stern - Neural Regeneration Research, 2024 - journals.lww.com
Parkinson's disease (PD) was first described as a neurological disease by Dr. James
Parkinson in 1817 as a “shaking palsy”. Since that time, much more is known about the …

Astrocytes regulate neuronal network burst frequency through NMDA receptors species-and donor-specifically

N Räsänen, J Tiihonen, M Koskuvi, Š Lehtonen… - bioRxiv, 2023 - biorxiv.org
Background Development of synaptic activity is a neuronal key characteristic that relies
largely on interactions between neurons and astrocytes. Although astrocytes have known …

[HTML][HTML] Astrocytes Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species-and Donor-Specific Manner

N Räsänen, J Tiihonen, M Koskuvi, Š Lehtonen… - … Psychiatry Global Open …, 2024 - Elsevier
Background Development of synaptic activity is a key neuronal characteristic that relies
largely on interactions between neurons and astrocytes. Although astrocytes have known …

Genetic Overlap Between Inflammatory Bowel Disease and Neurological Disorders: Insights from GWAS and Gene Expression Analysis

U Tripathi, Y Stern, I Dagan, R Nayak, E Romanovsky… - medRxiv, 2024 - medrxiv.org
Inflammatory Bowel Disease (IBD), which includes Crohn's disease (CD) and Ulcerative
Colitis (UC), is a complex and multifactorial condition marked by chronic inflammation of the …

Seeking convergence and divergence between autism and schizophrenia using genomic tools and patients' neurons

E Romanovsky, A Choudhary, AA Akel, S Stern - bioRxiv, 2023 - biorxiv.org
Autism spectrum disorders (ASDs) are a highly heritable and complex group of psychiatric
conditions resulting in abnormal repetitive behaviors and impairment in communication and …

[HTML][HTML] iPSC-derived hippocampal neurons from discordant monozygotic twins to understand the pathophysiology of Schizophrenia

A Choudhary - Neuroscience, 2024 - communities.springernature.com
Schizophrenia (SCZ) is characterized mainly by hallucinations, delusions, and mental
confusion and occurs at the rate of approximately 1% in the general population 1. Dr. Emile …