Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …

This chapter broadly reviews cardiopulmonary sympathetic and vagal sensors and their
reflex functions during physiologic and pathophysiologic processes. Mechanosensory …

The airways are densely innervated by sensory afferent nerves, whose activation regulates
respiration and triggers defensive reflexes (eg, cough, bronchospasm). Airway innervation is …

In our original white paper published in the The Journal of Physiology in 2016, we set out
our knowledge of the structural and functional organization of cardiac autonomic control …

Respiratory syncytial virus (RSV) primarily infects the respiratory epithelium, but growing
evidence suggests that it may also be responsible for neurologic sequelae. In 3-dimensional …

Resiniferatoxin (RTX), a selective transient receptor potential vanilloid 1 (TRPV1) receptor
agonist, can eliminate TRPV1+ primary sensory afferents and blunt cardiac sympathetic …

The lower airways (larynx to alveoli) are protected by a complex array of neural networks
that regulate respiration and airway function. Harmful stimuli trigger defensive responses …

Airway afferents monitor the local chemical and physical micro-environments in the airway
wall and lungs and send this information centrally to regulate neural circuits involved in …

Airway function is under constant neurophysiological control, in order to maximize airflow
and gas exchange and to protect the airways from aspiration, damage, and infection. There …

Myocardial ischemia causes the production and release of metabolites such as bradykinin,
which stimulates cardiac spinal sensory afferents, causing chest pain and an increase in …