In mammalian cells, autophagy is the major pathway for the degradation and recycling of
obsolete and potentially noxious cytoplasmic materials, including proteins, lipids, and whole …

The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-
angiogenic cancer therapy are major issues in almost all current concepts of both cancer …

Angiogenesis is regulated by the dynamic interaction between endothelial cells (ECs).
Hippo-Yes-associated protein (YAP) signalling has emerged as a key pathway that controls …

The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

Blood outgrowth endothelial cells (BOECs) are important tools when investigating diagnostic
and therapeutic approaches for vascular disease. In this protocol, mononuclear cells are …

Abstract Angiopoietin-2 (Ang-2) is a key mediator of vascular disease during sepsis, and
elevated plasma levels of Ang-2 are associated with organ injury scores and poor clinical …

Summary Weibel-Palade bodies (WPBs), endothelial-specific secretory granules that are
central to primary hemostasis and inflammation, occur in dimensions ranging between 0.5 …

The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood
flow into molecular signals responsible for a wide range of biological responses. Following …

Agonist-mediated exocytosis of Weibel-Palade bodies underpins the endothelium's ability to
respond to injury or infection. Much of this important response is mediated by the major …

MicroRNAs are endogenously expressed small noncoding RNAs that regulate gene
expression. Laminar blood flow induces atheroprotective gene expression in endothelial …