Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition
leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular …

In recent years, the tissue engineering paradigm has shifted to include a new and growing
subfield of scaffoldless techniques that generate self-organizing and self-assembling …

Corneal blindness is a major cause of blindness in the world and corneal transplantation is
the only widely accepted treatment to restore sight in these eyes. However, it is becoming …

Corneal blindness afflicts millions of individuals worldwide and is currently treated by
grafting with cadaveric tissues; however, there are worldwide donor tissue shortages, and …

In this project, we strived to develop a decellularized human cornea to use as a scaffold for
reconstructing the corneal epithelium and anterior stroma. Human cadaver corneas were …

Recent breakthroughs in regenerative medicine have generated enthusiasm and many
efforts to explore new therapeutic potentials of both somatic and pluripotent stem cells …

Purpose The purpose of this study was to produce and characterize human tissue-
engineered corneas reconstructed using all three corneal cell types (epithelial, stromal, and …

The self-assembly approach is based on the capability of mesenchymal cells to secrete and
organize their own extracellular matrix (ECM). This tissue engineering method allows for the …

Each day, about 2000 US workers have a job-related eye injury requiring medical treatment.
Corneal diseases are the fifth cause of blindness worldwide. Most of these diseases can be …

Abstract Development of implantable devices based on the principles of in vitro
organogenesis has been hindered due to the prolonged time required to develop an …