Mammalian cells contain 100 or more copies of tandemly repeated ribosomal RNA (rRNA)
genes per haploid genome. These genes are transcribed with high efficiency to keep up with …

The ribosome is the enzymatic macromolecular machine responsible for protein synthesis.
The rates of protein synthesis are primarily dependent on translational efficiency and …

Transcription of ribosomal RNA by RNA polymerase (Pol) I initiates ribosome biogenesis
and regulates eukaryotic cell growth. The crystal structure of Pol I from the yeast …

Cell growth (increase in cell mass or size) is tightly coupled to nutrient availability, growth
factors and the energy status of the cell. The target of rapamycin (TOR) integrates all three …

The regulation of ribosome biogenesis in response to environmental conditions is a key
aspect of cell growth control. Ribosomal protein (RP) genes are regulated by the nutrient …

Nucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus,
ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins. RNA …

Genes encoding rRNA are multicopy and thus could be regulated by changing the number
of active genes or by changing the transcription rate per gene. We tested the hypothesis that …

Abstract RNA Polymerase (Pol) I produces ribosomal (r) RNA, an essential component of the
cellular protein synthetic machinery that drives cell growth, underlying many fundamental …

Protein biosynthesis depends on the availability of ribosomes, which in turn relies on
ribosomal RNA production. In eukaryotes, this process is carried out by RNA polymerase I …

In the extensive network of interdependent biochemical processes required for cell growth
and division, there is mounting evidence that ribosomal DNA transcription by RNA …