Exploring multivalent carbohydrate–protein interactions by NMR

JI Quintana, U Atxabal, L Unione, A Ardá… - Chemical Society …, 2023 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) has been widely employed to assess diverse features
of glycan–protein molecular recognition events. Different types of qualitative and quantitative …

ALKBH5‐Mediated RNA m6A Methylation Regulates the Migration, Invasion, and Proliferation of Rheumatoid Fibroblast‐Like Synoviocytes

Y Kuang, R Li, J Wang, S Xu, Q Qiu, S Lin… - Arthritis & …, 2024 - Wiley Online Library
Objective Fibroblast‐like synoviocytes (FLSs) are critical for promoting joint damage in
rheumatoid arthritis (RA). N 6‐methyladenosine (m6A) modification plays key roles in …

Short term, low dose alpha-ketoglutarate based polymeric nanoparticles with methotrexate reverse rheumatoid arthritis symptoms in mice and modulate T helper cell …

JL Mangal, S Inamdar, AP Suresh… - Biomaterials …, 2022 - pubs.rsc.org
Activated effector T cells induce pro-inflammatory responses in rheumatoid arthritis (RA)
which then lead to inflammation of the joints. In this report, we demonstrate that polymeric …

Exploring the therapeutic opportunities of potassium channels for the treatment of rheumatoid arthritis

NE More, R Mandlik, S Zine, VS Gawali… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects the
synovial joint, which leads to inflammation, loss of function, joint destruction, and disability …

Curcumin-laden amphiphilic chitosan microemulsion with enhanced transdermal delivery, skin compatibility and anti-arthritic activity

J Zhang, Z Wang, M Liao, S Li, Q Feng… - Journal of Drug Delivery …, 2022 - Elsevier
Transdermal administration can avoid the first-pass effect of liver, improve the bioavailability
of drugs and the adaptability of patients. However, there are still many problems, such as …

Extracellular polysaccharides from Sporidiobolus pararoseus alleviates rheumatoid through ameliorating gut barrier function and gut microbiota

T Liao, F Shen, H Zhu, W Mu, H Qian, Y Liu - International Journal of …, 2024 - Elsevier
Rheumatoid arthritis (RA) is becoming a prevalent autoimmune disease affecting people
worldwide, necessitating the exploration of novel therapeutic approaches due to the …

Tanshinone I inhibits the functions of T lymphocytes and exerts therapeutic effects on delayed-type hypersensitivity reaction via blocking STATs signaling pathways

Z Lu, H Liao, M Zhang, M Huang, M Du, Y Wang… - European Journal of …, 2024 - Elsevier
Delayed-type hypersensitivity (DTH) reactions are a kind of chronic inflammatory diseases
initiated by antigens and antigen-specific T cells. Currently, the therapy of DTH reactions is …

Improvement of Refractory Chronic Actinic Dermatitis During Tofacitinib Treatment

YJ Wang, HZ Hui, JR Cheng, H Mao… - American Journal of …, 2023 - journals.lww.com
To the Editor: Chronic actinic dermatitis (CAD) is a refractory, recurrent, immune-mediated
photosensitive skin disease, which mainly appears as chronic dermatitis changes in …

Designing Metabolite-based Therapies to Rewire Immunometabolism and Treat Autoimmune Rheumatoid Arthritis

JL Mangal - 2022 - search.proquest.com
Autoimmunity develops when the immune system targets self-antigens within the body.
Rheumatoid arthritis (RA) is a common autoimmune disease, and its progression is …