Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among
patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications …

ROS are a group of small reactive molecules that play critical roles in the regulation of
various cell functions and biological processes. In the vascular system, physiological levels …

Grape seed oil is rich in phenolic compounds, fatty acids, and vitamins, with economic
importance to pharmaceutical, cosmetic, and food industry. Its use as an edible oil has also …

Diabetic nephropathy (DN), a microvascular complication of diabetes, has emerged as an
important health problem worldwide. There is strong evidence to suggest that oxidative …

Arterial stiffness is a major independent risk factor for cardiovascular complications causing
isolated systolic hypertension and increased pulse pressure in the microvasculature of …

Mechanical stress from blood flow has a significant effect on endothelial physiology, with a
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …

Aims: To investigate a possible link between hemodynamic shear stress, reactive oxygen
species (ROS) generation, and proprotein convertase subtilisin/kexin type 9 (PCSK9) …

The aorta is a blood vessel that provides a low-resistance path for blood flow directed from
the heart to peripheral organs and tissues. However, the aorta has another central …

Background—Stiffening of the aortic wall is a phenomenon consistently observed in age and
in abdominal aortic aneurysm (AAA). However, its role in AAA pathophysiology is largely …

Although the complex mechanism by which skeletal tissue heals has been well described,
the role of reactive oxygen species (ROS) in skeletal tissue regeneration is less understood …