The immunosuppressive effect of adenosine in the microenvironment of a tumor is well
established. Presently, researchers are developing approaches in immune therapy that …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

CD73 is a novel immune checkpoint associated with adenosine metabolism that promotes
tumor progression by suppressing antitumor immune response and promoting …

Adenosine is a regulatory molecule with widespread physiological effects in almost every
cells and acts as a potent regulator of cell growth. Adenosine has been shown to inhibit cell …

Abnormal lipid metabolism is a common feature in most solid tumors, and occurs in early
stages of the tumor progression. As benign breast tumor is different from malignant tumor of …

Human adenosine deaminase 1 deficiency was described in the 1970s to cause severe
combined immunodeficiency. The residual adenosine deaminase activity in these patients …

Cordycepin gets rapidly metabolized in the body into inactive form due to its structural
similarity to adenosine, thus inhibiting its development as a medicinal agent. This study was …

Objective Adenosine deaminase (ADA) plays an important role in immune response, which
includes two isoenzymes: ADA1 and ADA2. This study aims to explore the roles of ADA1 …

Background In the era of immunotherapy, predictive or prognostic biomarkers for head and
neck squamous cell carcinoma (HNSCC) are urgently needed. Metabolic reprogramming in …

Adenosine deaminase is a critical enzyme in purine metabolism that regulates intra and
extracellular adenosine concentrations by converting it to inosine. Adenosine is an important …