Stem cell based therapies for age-related macular degeneration: the promises and the challenges

H Nazari, L Zhang, D Zhu, GJ Chader… - Progress in retinal and …, 2015 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …

Cell-based therapy for degenerative retinal disease

M Zarbin - Trends in molecular medicine, 2016 - cell.com
Stem cell-derived retinal pigment epithelium (RPE) and photoreceptors (PRs) have restored
vision in preclinical models of human retinal degenerative disease. This review discusses …

Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration

B Lu, C Malcuit, S Wang, S Girman, P Francis… - Stem …, 2009 - academic.oup.com
Assessments of safety and efficacy are crucial before human ESC (hESC) therapies can
move into the clinic. Two important early potential hESC applications are the use of retinal …

Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics

I Klimanskaya, J Hipp, KA Rezai, M West… - Cloning and stem …, 2004 - liebertpub.com
Human stem-cell derivatives are likely to play an important role in the future of regenerative
medicine. Evaluation and comparison to their in vivo counterparts is critical for assessment …

Human embryonic stem cell–derived cells rescue visual function in dystrophic RCS rats

RD Lund, S Wang, I Klimanskaya, T Holmes… - Cloning and stem …, 2006 - liebertpub.com
Embryonic stem cells promise to provide a well-characterized and reproducible source of
replacement tissue for human clinical studies. An early potential application of this …

Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease

RD Lund, S Wang, B Lu, S Girman, T Holmes… - Stem …, 2007 - academic.oup.com
Progressive photoreceptor degeneration resulting from genetic and other factors is a leading
and largely untreatable cause of blindness worldwide. The object of this study was to find a …

Development of human embryonic stem cell therapies for age-related macular degeneration

AJF Carr, MJK Smart, CM Ramsden, MB Powner… - Trends in …, 2013 - cell.com
Age-related macular degeneration (AMD) is the leading cause of vision loss in older adults
and ultimately leads to the death of photoreceptor cells in the macular area of the neural …

[HTML][HTML] In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells

M Haruta, Y Sasai, H Kawasaki… - … & visual science, 2004 - jov.arvojournals.org
purpose. To determine whether primate embryonic stem (ES) cell-derived pigment epithelial
cells (ESPEs) have the properties and functions of retinal pigment epithelial (RPE) cells in …

RPE transplantation and its role in retinal disease

L da Cruz, FK Chen, A Ahmado, J Greenwood… - Progress in retinal and …, 2007 - Elsevier
Retinal pigment epithelial (RPE) transplantation aims to restore the subretinal anatomy and
re-establish the critical interaction between the RPE and the photoreceptor, which is …

Treatment of retinitis pigmentosa with human umbilical cord cells

S Mistry, DJ Messina, IR Harris, AM Harmon… - US Patent …, 2008 - Google Patents
US7413734B2 - Treatment of retinitis pigmentosa with human umbilical cord cells - Google
Patents US7413734B2 - Treatment of retinitis pigmentosa with human umbilical cord cells …