Background: Mild to moderate hypothermia (32–35 C) is the first treatment with proven
efficacy for postischemic neurological injury. In recent years important insights have been …

Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …

Background Cardiac arrest outside the hospital is common and has a poor outcome. Studies
in laboratory animals suggest that hypothermia induced shortly after the restoration of …

Background Cardiac arrest with widespread cerebral ischemia frequently leads to severe
neurologic impairment. We studied whether mild systemic hypothermia increases the rate of …

Induced hypothermia can be used to protect the brain from post-ischemic and traumatic
neurological injury. Potential clinical applications and the available evidence are discussed …

Objective Hypothermia has been used for medicinal purposes since ancient times. This
paper reviews the current potential clinical applications for mild hypothermia (32–35° C) …

Neurologic complications after cardiac surgery are of growing importance for an aging
surgical population. In this review, we provide a critical appraisal of the impact of current …

Object. Induced hypothermia in patients with severe head injury may prevent additional
brain injury and improve outcome. However, this treatment is associated with severe side …

We previously found mild hypothermia (34–36° C), induced before cardiac arrest, to improve
neurologic outcome. In this study we used a reproducible dog model to evaluate mild …

Selective neuronal cell death in the CA, pyramidal cells of the hippocampus and neurons of
the dorsolateral striatum as a consequence of brain ischemia/reperfusion (IR) can be …