Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

The CRISPR-Cas system has undoubtedly revolutionized the genome editing field, enabling
targeted gene disruption, regulation, and recovery in a guide RNA-specific manner. In this …

The cancer mortality rate of hepatocellular carcinoma (HCC) is the second highest in the
world and the therapeutic options are limited. The incidence of this deadly cancer is rising at …

Non-alcoholic fatty liver disease is a chronic liver abnormality that exhibits high variability
and can lead to liver cancer in advanced stages. Hepatic ablation of SIRT6 results in fatty …

Protein SUMOylation modification conjugated with small ubiquitin‐like modifiers (SUMOs) is
one kind of PTMs, which exerts comprehensive roles in cellular functions, including gene …

Purpose Unpredictable genetic modifications and chromosomal aberrations following
CRISPR/Cas9 administration hamper the efficacy of germline editing. Repair events …

The ability to edit DNA at the nucleotide level using clustered regularly interspaced short
palindromic repeats (CRISPR) systems is a relatively new investigative tool that is …

Background Genetic skeletal dysplasia conditions (GSDs) account for 5% of all birth defects.
Until recently, targeted treatments were only available for select few conditions; however …

Receptor tyrosine kinases (RTKs) control fundamental cellular processes and their signal
transduction is essential in skeletal, nervous, and vascular development. RTKs are activated …

Studies which seek fundamental, thorough knowledge of biological processes, and
continuous advancement in natural sciences and biotechnology enable the establishment of …