One of the hallmarks of cancer is the ability to generate and withstand unusual levels of
oxidative stress. In part, this property of tumor cells is conferred by elevation of the cellular …

Background: Glutathione is a key scavenging antioxidant that opposes the proinflammatory
signaling of hydrogen peroxide. Boosting cellular glutathione levels may have broad utility in …

When rat dams consume a diet low in protein during pregnancy, their offspring develop high
blood pressure. On a low-protein diet, the endogenous formation of the amino acid glycine is …

In a previous paper, we pointed out that the capability to synthesize glycine from serine is
constrained by the stoichiometry of the glycine hydroxymethyltransferase reaction, which …

The endogenous organic acid metabolic acidoses that occur commonly in adults include
lactic acidosis; ketoacidosis; acidosis that results from the ingestion of toxic substances such …

A number of endogenous and xenobiotic organic acids are conjugated to glycine, in animals
ranging from mosquitoes to humans. Glycine conjugation has generally been assumed to be …

Background The finding that plasma glutathione turnover decreases as dietary protein
intake decreases suggests that the safe amount of dietary protein, although sufficient for …

Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is associated with
increased incidence of dialysis dependence and portends high mortality in critically ill …

Background: Biuret assays for total protein measurement are considered to react with all
peptides longer than 2 residues. Some studies using biuret assays of urine suggest that …

We hypothesized that a limitation in the endogenous formation of glycine might constrain
catch-up growth during recovery from severe childhood malnutrition. The urinary excretion of …