The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

Oxidative stress is increased in systemic lupus erythematosus (SLE), and it contributes to
immune system dysregulation, abnormal activation and processing of cell-death signals …

Systemic lupus erythematosus (SLE) is an autoimmune disease that has diverse clinical
manifestations, ranging from restricted cutaneous involvement to life-threatening systemic …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

Women develop chronic inflammatory autoimmune diseases more often than men. The
mechanisms causing the increased susceptibility are incompletely understood. Chronic …

Aberrant expression of microRNAs (miRNAs) has been identified in various diseases.
Recent studies demonstrated that miRNAs can be detected in the circulation and serve as …

T cells contribute to the initiation and perpetuation of autoimmunity in systemic lupus
erythematosus (SLE), and seem to be directly involved in the development of related organ …

Self tolerance loss is fundamental to autoimmunity. While understanding of immune
regulation is expanding rapidly, the mechanisms causing loss of tolerance in most …

Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Despite years
of study, the etiology of SLE is still unclear. Both genetic and environmental factors have …

Systemic lupus erythematosus is a chronic-relapsing autoimmune disease of incompletely
understood etiology. Recent evidence strongly supports an epigenetic contribution to the …