IL-17 and IL-17-producing cells in protection versus pathology

KHG Mills - Nature Reviews Immunology, 2023 - nature.com
IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Clinical Impact of Staphylococcus aureus Skin and Soft Tissue Infections

MS Linz, A Mattappallil, D Finkel, D Parker - Antibiotics, 2023 - mdpi.com
The pathogenic bacterium Staphylococcus aureus is the most common pathogen isolated in
skin-and-soft-tissue infections (SSTIs) in the United States. Most S. aureus SSTIs are caused …

Exploring the Role of Staphylococcus aureus in Inflammatory Diseases

H Chen, J Zhang, Y He, Z Lv, Z Liang, J Chen, P Li… - Toxins, 2022 - mdpi.com
Staphylococcus aureus is a very common Gram-positive bacterium, and S. aureus infections
play an extremely important role in a variety of diseases. This paper describes the types of …

Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

J Clegg, E Soldaini, RM McLoughlin… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …

[HTML][HTML] Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis

JE Gudjonsson, LC Tsoi, F Ma, AC Billi… - JCI insight, 2020 - ncbi.nlm.nih.gov
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease
characterized by chronic abscess formation and development of multiple draining sinus …

Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms

LS Miller, VG Fowler Jr, SK Shukla… - FEMS microbiology …, 2020 - academic.oup.com
Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in
both hospital and community settings, especially with the widespread emergence of virulent …

Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes

MA Ataide, K Knöpper, PC de Casas, M Ugur… - Immunity, 2022 - cell.com
Lymphatic transport of molecules and migration of myeloid cells to lymph nodes (LNs)
continuously inform lymphocytes on changes in drained tissues. Here, using LN …

Competition between skin antimicrobial peptides and commensal bacteria in type 2 inflammation enables survival of S. aureus

T Nakatsuji, SL Brinton, KJ Cavagnero, AM O'Neill… - Cell reports, 2023 - cell.com
During inflammation, the skin deploys antimicrobial peptides (AMPs) yet during allergic
inflammation it becomes more susceptible to Staphylococcus aureus. To understand this …

γδ T cells in cancer: a small population of lymphocytes with big implications

M Raverdeau, SP Cunningham… - Clinical & …, 2019 - Wiley Online Library
Abstract γδ T cells are a small population of mostly tissue‐resident lymphocytes, with both
innate and adaptive properties. These unique features make them particularly attractive …

Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease

GJ Patrick, H Liu, MP Alphonse… - The Journal of …, 2021 - Am Soc Clin Investig
IgE induced by type 2 immune responses in atopic dermatitis is implicated in the
progression of atopic dermatitis to other allergic diseases, including food allergies, allergic …