The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Q Ning, D Wu, X Wang, D Xi, T Chen, G Chen… - Signal transduction and …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …

NAD+ in COVID-19 and viral infections

M Zheng, MB Schultz, DA Sinclair - Trends in Immunology, 2022 - cell.com
NAD+, as an emerging regulator of immune responses during viral infections, may be a
promising therapeutic target for coronavirus disease 2019 (COVID-19). In this Opinion, we …

COVID‐19 metabolism: Mechanisms and therapeutic targets

T Wang, Y Cao, H Zhang, Z Wang, CH Man… - MedComm, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) dysregulates antiviral
signaling, immune response, and cell metabolism in human body. Viral genome and …

Redox regulation and metabolic dependency of Zika virus replication: Inhibition by Nrf2-antioxidant response and NAD (H) antimetabolites

BR Sahoo, AA Crook, A Pattnaik… - Journal of …, 2023 - Am Soc Microbiol
Viral infections alter host cell metabolism and homeostasis; however, the mechanisms that
regulate these processes have only begun to be elucidated. We report here that Zika virus …

Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems

GG Nicastro, AM Burroughs, LM Iyer… - Nucleic Acids …, 2023 - academic.oup.com
While nucleic acid-targeting effectors are known to be central to biological conflicts and anti-
selfish element immunity, recent findings have revealed immune effectors that target their …

Nicotinamide mononucleotide (NMN) alleviates the poly (I: C)-induced inflammatory response in human primary cell cultures

H Sano, A Kratz, T Nishino, H Imamura, Y Yoshida… - Scientific Reports, 2023 - nature.com
NMN is the direct precursor of nicotinamide adenine dinucleotide (NAD+) and is considered
as a key factor for increasing NAD+ levels and mitochondrial activity in cells. In this study …

Hypocortisolemic ASIA: a vaccine-and chronic infection-induced syndrome behind the origin of long COVID and myalgic encephalomyelitis

M Ruiz-Pablos, B Paiva, A Zabaleta - Frontiers in Immunology, 2024 - frontiersin.org
Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), long COVID (LC) and
post-COVID-19 vaccine syndrome show similarities in their pathophysiology and clinical …

In search of the Aplysia immunome: an in silico study

NS Kron - BMC genomics, 2022 - Springer
The immune repertoires of mollusks beyond commercially important organisms such as the
pacific oyster Crassostrea gigas or vectors for human pathogens like the bloodfluke planorb …

Apprehending the NAD+–ADPr-Dependent Systems in the Virus World

LM Iyer, AM Burroughs, V Anantharaman, L Aravind - Viruses, 2022 - mdpi.com
NAD+ and ADP-ribose (ADPr)-containing molecules are at the interface of virus–host
conflicts across life encompassing RNA processing, restriction, lysogeny/dormancy and …

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

B Klabunde, A Wesener, W Bertrams, I Beinborn… - Nature …, 2023 - nature.com
Lower respiratory tract infections caused by Streptococcus pneumoniae (Spn) are a leading
cause of death globally. Here we investigate the bronchial epithelial cellular response to …