MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
Myc and cell cycle control
G Bretones, MD Delgado, J León - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
Soon after the discovery of the Myc gene (c-Myc), it became clear that Myc expression levels
tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …
tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …
c-Myc target genes involved in cell growth, apoptosis, and metabolism
CV Dang - Molecular and cellular biology, 1999 - Taylor & Francis
The c-myc gene was discovered as the cellular homolog of the retroviral v-myc oncogene 20
years ago (23, 25, 167). The c-myc proto-oncogene was subsequently found to be activated …
years ago (23, 25, 167). The c-myc proto-oncogene was subsequently found to be activated …
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.
F Chang, LS Steelman, JT Lee… - Leukemia …, 2003 - search.ebscohost.com
Abstract The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-
signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to …
signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to …
Cyclins and cancer II: cyclin D and CDK inhibitors come of age
It is 3 years since our minireview on cyclins and cancer (Hunter and Pines, 1991), and in that
time the number of connections between oncogenesis and the components that regulate the …
time the number of connections between oncogenesis and the components that regulate the …
Endocrine resistance in breast cancer: from molecular mechanisms to therapeutic strategies
Abstract Estrogen receptor-positive (ER+) breast cancer accounts for approximately 75% of
all breast cancers. Endocrine therapies, including selective ER modulators (SERMs) …
all breast cancers. Endocrine therapies, including selective ER modulators (SERMs) …
Proteins of the Myc network: essential regulators of cell growth and differentiation
M Henriksson, B Lüscher - Advances in cancer research, 1996 - Elsevier
Publisher Summary This chapter focuses on the proteins of the Myc network that are
essential regulators of cell growth and differentiation. The identification of the Myc partner …
essential regulators of cell growth and differentiation. The identification of the Myc partner …
Ras enhances Myc protein stability
Various experiments have demonstrated a collaborative action of Myc and Ras, both in
normal cell growth control as well as during oncogenesis. We now show that Ras enhances …
normal cell growth control as well as during oncogenesis. We now show that Ras enhances …
Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway
F Chang, LS Steelman, JG Shelton… - International …, 2003 - spandidos-publications.com
Abstract The Ras/Raf/MEK/ERK signal transduction pathway regulates cell cycle
progression and apoptosis in diverse types of cells. Mutations in this pathway are often …
progression and apoptosis in diverse types of cells. Mutations in this pathway are often …
[HTML][HTML] Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
C Bouchard, K Thieke, A Maier, R Saffrich… - The EMBO …, 1999 - embopress.org
Ectopic expression of Myc induces Cdk2 kinase activity in quiescent cells and antagonizes
association of p27 kip1 with Cdk2. The target gene (s) by which Myc mediates this effect is …
association of p27 kip1 with Cdk2. The target gene (s) by which Myc mediates this effect is …