The neurological toxicity of heavy metals: A fish perspective
AJ Green, A Planchart - Comparative Biochemistry and Physiology Part C …, 2018 - Elsevier
The causes of neurodegenerative diseases are complex with likely contributions from
genetic susceptibility and environmental exposures over an organism's lifetime. In this …
genetic susceptibility and environmental exposures over an organism's lifetime. In this …
The role of altered protein acetylation in neurodegenerative disease
Acetylation is a key post-translational modification (PTM) involved in the regulation of both
histone and non-histone proteins. It controls cellular processes such as DNA transcription …
histone and non-histone proteins. It controls cellular processes such as DNA transcription …
HDAC1 regulates fear extinction in mice
S Bahari-Javan, A Maddalena… - Journal of …, 2012 - Soc Neuroscience
Histone acetylation has been implicated with the pathogenesis of neuropsychiatric disorders
and targeting histone deacetylases (HDACs) using HDAC inhibitors was shown to be …
and targeting histone deacetylases (HDACs) using HDAC inhibitors was shown to be …
Transcriptional repressors: multifaceted regulators of gene expression
N Reynolds, A O'Shaughnessy, B Hendrich - Development, 2013 - journals.biologists.com
Through decades of research it has been established that some chromatin-modifying
proteins can repress transcription, and thus are generally termed 'repressors'. Although …
proteins can repress transcription, and thus are generally termed 'repressors'. Although …
HDAC signaling in neuronal development and axon regeneration
Highlights•HDACs function in the differentiation of neuronal progenitor cells to neurons
during development as well as in the adult brain.•HDAC family members have very specific …
during development as well as in the adult brain.•HDAC family members have very specific …
Genome wide expression profiling during spinal cord regeneration identifies comprehensive cellular responses in zebrafish
Background Among the vertebrates, teleost and urodele amphibians are capable of
regenerating their central nervous system. We have used zebrafish as a model to study …
regenerating their central nervous system. We have used zebrafish as a model to study …
Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: therapeutic implications for Parkinson's disease
BR Pinho, SD Reis, P Guedes-Dias… - Pharmacological …, 2016 - Elsevier
Histone deacetylases (HDACs) are key epigenetic enzymes and emerging drug targets in
cancer and neurodegeneration. Pan-HDAC inhibitors provided neuroprotection in …
cancer and neurodegeneration. Pan-HDAC inhibitors provided neuroprotection in …
Role of epigenetics in zebrafish development
S Balasubramanian, A Raghunath, E Perumal - Gene, 2019 - Elsevier
The role of epigenetics in development has garnered attention in recent years due to their
ability to modulate the embryonic developmental gene expression in response to the …
ability to modulate the embryonic developmental gene expression in response to the …
Diallyl disulfide-induced apoptosis in a breast-cancer cell line (MCF-7) may be caused by inhibition of histone deacetylation
The health benefits of garlic have been proven by epidemiological and experimental
studies. Diallyl disulphide (DADS), the major organosulfur compound found in garlic oil, is …
studies. Diallyl disulphide (DADS), the major organosulfur compound found in garlic oil, is …
Dual regulation of lin28a by Myc is necessary during zebrafish retina regeneration
Cellular reprogramming leading to induction of Muller glia–derived progenitor cells
(MGPCs) with stem cell characteristics is essential for zebrafish retina regeneration …
(MGPCs) with stem cell characteristics is essential for zebrafish retina regeneration …