Lacking conventional lymphatic system, the central nervous system requires alternative
clearance systems, such as the glymphatic system, which promotes clearance of interstitial …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Animal studies implicate meningeal lymphatic dysfunction in the pathogenesis of
neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD) …

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

The neurovascular system (NVS), which consisted of neurons, glia, and vascular cells, is a
functional and structural unit of the brain. The NVS regulates blood-brain barrier (BBB) …

Diseases and aging-associated alterations of the nervous system often show sex-specific
characteristics. Glial cells play a major role in the endogenous homeostatic response of …

Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …

The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …

Assessing glymphatic function using in-vivo imaging method is of great value for
understanding its contribution to major brain diseases. In the present study, we aim to …

COVID-19, initially regarded as specific lung disease, exhibits an extremely broad spectrum
of symptoms. Extrapulmonary manifestations of the disease also include important …