Small-angle X-ray scattering (SAXS) is a biophysical method to study the overall shape and
structural transitions of biological macromolecules in solution. SAXS provides low resolution …

The neurotransmitters GABA and glycine mediate fast synaptic inhibition by activating ligand-
gated chloride channels—namely, type A GABA (GABAA) and glycine receptors. Both types …

Dynamic ensembles of macromolecules mediate essential processes in biology.
Understanding the mechanisms driving the function and molecular interactions …

GABAA receptors (GABAAR s) are ligand‐gated Cl− channels that mediate most of the fast
inhibitory neurotransmission in the central nervous system (CNS). Multiple GABAAR …

Phase separation drives compartmentalization of intracellular contents into various
biomolecular condensates. Individual condensate components are thought to differentially …

The strychnine-sensitive pentameric glycine receptor (GlyR) mediates fast inhibitory
neurotransmission in the mammalian nervous system. Only heteromeric GlyRs mediate …

The molybdenum cofactor (Moco) represents an ancient metal‑sulfur cofactor, which
participates as catalyst in carbon, nitrogen and sulfur cycles, both on individual and global …

Inhibitory synapses are also known as symmetric synapses due to their lack of prominent
postsynaptic densities (PSDs) under a conventional electron microscope (EM). Recent cryo …

Molybdenum cofactor (Moco) deficiency (MoCD) is characterized by neonatal-onset
myoclonic epileptic encephalopathy and dystonia with cerebral MRI changes similar to …

Scaffolding proteins underlying postsynaptic membrane specializations are important
structural and functional components of both excitatory and inhibitory synapses. At inhibitory …