Abstract A thiazolidine-2, 4-dione nucleus was molecularly hybridised with the effective
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …

In the current study, we report on the development of novel series of pyrazolo [3, 4-b]
pyridine derivatives (8a-u, 11a-n, and 14a, b) as potential anticancer agents. The prepared …

Human health is experiencing several obstacles in the modern medical era, particularly
cancer. As a result, the cancer therapeutic arsenal should be continually expanded with …

In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (5a–e
and 7a–i) was designed and synthesised. The anticancer activity for compounds (5b–d, 7a …

LSM-83177, a phenoxy acetic acid derivative, is a small molecule reported for its promising
anti-tumor properties. Via inhibiting the interaction between MDM2 and p53, LSM-83177 can …

In an effort to support the global fight against tuberculosis (TB), which is widely recognized
as the most lethal infectious disease worldwide, we present the design and synthesis of new …

The present study aimed to investigate in-depth a cytotoxic novel benzofuran-isatin
conjugate (5a, 3-methyl-N'-(2-oxoindolin-3-ylidene) benzofuran-2-carbohydrazide) with …

A novel series of 2-thioacetamide linked benzoxazole-benzamide conjugates 1–15 was
designed as potential inhibitors of the vascular endothelial growth factor receptor-2 (VEGFR …

BACKGROUND Colorectal cancer (CRC) has a high incidence and mortality. Recent studies
have shown that indole derivatives involved in gut microbiota metabolism can impact the …

Enzyme inhibition is an important process in the mode of action of many drugs used in the
treatment of various diseases. Antibiotics, anti-hypertensive agents, anti-hyperlipidaemic …