Amyotrophic lateral sclerosis: translating genetic discoveries into therapies

F Akçimen, ER Lopez, JE Landers, A Nath… - Nature Reviews …, 2023 - nature.com
Recent advances in sequencing technologies and collaborative efforts have led to
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …

Blood biomarkers in ALS: challenges, applications and novel frontiers

E Sturmey, A Malaspina - Acta Neurologica Scandinavica, 2022 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease among
adults. With diagnosis reached relatively late into the disease process, extensive motor cell …

Neutrophils Are Associated with Higher Risk of Incident Amyotrophic Lateral Sclerosis in a BMI‐and Age‐Dependent Manner

W Cao, Z Cao, Y Tian, L Zhang, W Wang… - Annals of …, 2023 - Wiley Online Library
Objective Peripheral immune markers have been associated with the progression and
prognosis of amyotrophic lateral sclerosis (ALS). However, whether dysregulation of …

Extracellular vesicles in amyotrophic lateral sclerosis

G McCluskey, KE Morrison, C Donaghy, F Rene… - Life, 2022 - mdpi.com
Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disease and is the most
common adult motor neuron disease. The disease pathogenesis is complex with the …

Abnormal energy metabolism in ALS: a key player?

T Burg, L Van Den Bosch - Current opinion in neurology, 2023 - journals.lww.com
Abnormal energy metabolism in ALS: a key player? : Current Opinion in Neurology
Abnormal energy metabolism in ALS: a key player? : Current Opinion in Neurology Log in …

Risk factors associated with amyotrophic lateral sclerosis based on the observational study: a systematic review and meta-analysis

Q Zhu, J Zhou, Y Zhang, H Huang, J Han… - Frontiers in …, 2023 - frontiersin.org
Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting
the upper and lower motor neurons. Though the pathogenesis of ALS is still unclear …

[HTML][HTML] The role of sphingomyelin and ceramide in motor neuron diseases

G McCluskey, C Donaghy, KE Morrison… - Journal of personalized …, 2022 - mdpi.com
Amyotrophic Lateral Sclerosis (ALS), Spinal Bulbar Muscular Atrophy (SBMA), and Spinal
Muscular Atrophy (SMA) are motor neuron diseases (MNDs) characterised by progressive …

Apolipoproteins, lipids, lipid-lowering drugs and risk of amyotrophic lateral sclerosis and frontotemporal dementia: a meta-analysis and Mendelian randomisation …

CV Chalitsios, H Ley, J Gao, MR Turner… - Journal of …, 2024 - Springer
Background Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have
clinical, pathological and genetic overlapping. Lipid pathways are implicated in ALS. This …

Presymptomatic amyotrophic lateral sclerosis: from characterization to prevention

M Benatar, MR Turner, J Wuu - Current opinion in neurology, 2023 - journals.lww.com
Presymptomatic amyotrophic lateral sclerosis: from character... : Current Opinion in Neurology
Presymptomatic amyotrophic lateral sclerosis: from characterization to prevention : Current …

[HTML][HTML] Associations of environmental factors with neurodegeneration: An exposome-wide Mendelian randomization investigation

D Li, L Zhou, Z Cao, J Wang, H Yang, M Lyu… - Ageing Research …, 2024 - Elsevier
Neurodegenerative diseases (NDDs) remain a global health challenge. Previous studies
have reported potential links between environmental factors and NDDs, however, findings …