The assembly of the five oxidative phosphorylation system (OXPHOS) complexes in the
inner mitochondrial membrane is an intricate process. The human enzymes comprise core …

Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen
consumption and is essential for aerobic energy generation in the form of ATP. Human COX …

Copper is too redox active to exist in an unbound form in the cell without causing oxidative
damage: an upper limit of 10-18 M for the free concentration of Cu (II) in unstressed cells has …

The current state of knowledge on how copper metallochaperones support the maturation of
cuproproteins is reviewed. Copper is needed within mitochondria to supply the CuA and …

Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

Biological copper is coordinated predominantly by just three ligand types: the side chains of
histidine, cysteine, and methionine, with of course some exceptions. The arrangement of …

We describe here a pathway for the import of proteins into the intermembrane space (IMS) of
mitochondria. Substrates of this pathway are proteins with conserved cysteine motifs, which …

Copper (Cu) is an essential trace element for all living organisms and used as cofactor in
key enzymes of important biological processes, such as aerobic respiration or superoxide …

Mitochondrial cytochrome c oxidase (CcO) or respiratory chain complex IV is a heme aa 3-
copper oxygen reductase containing metal centers essential for holo-complex biogenesis …

This article deals with the solution structure determination of paramagnetic metalloproteins
by NMR spectroscopy. These proteins were believed not to be suitable for NMR …