Expression of the genes that mediate the first steps in steroidogenesis, the steroidogenic
acute regulatory protein (STARD1), the cholesterol side-chain cleavage enzyme …

The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP, encoded by
the NR5A1 gene) is an essential regulator of endocrine development and function. Initially …

Anti–Müllerian hormone (AMH) produced by ovarian granulosa cells (GCs) plays a crucial
role in ovarian function. It is used as a diagnostic and/or prognostic marker of fertility as well …

Nuclear hormone receptors (NRs) are evolutionarily conserved ligand-dependent
transcription factors. They are essential for human life, mediating the actions of lipophilic …

It is well established that stress, either physical or psychosocial, causes a decrease in
testosterone production by Leydig cells. Glucocorticoids (Gc) are the main mediators of …

Several signals, such as hormones and signaling molecules, have been identified as
important regulators of Leydig cell differentiation and function. Conveying these signals and …

Introduction: The orphan nuclear receptor Nur77 (also known as NR4A1, NGFIB, TR3, TIS1,
NAK-1, or N10) is a unique transcription factor encoded by an immediate early gene. Nur77 …

The DEAD-box helicase DP103 (Ddx20, Gemin3) is a multifunctional protein that interacts
with Epstein-Barr virus nuclear proteins (EBNA2/EBNA3) and is a part of the spliceosomal …

Cell migration plays major roles in human breast cancer-related death, but the molecular
mechanisms remain unclear. Valproic acid (VPA) is a broad-spectrum inhibitor of class I and …

Intranasal administration of hormone replacement therapy presents an original plasma
kinetic profile with transient estrogen levels giving rise to the concept of pulsed therapy. To …