Since tyrosine phosphorylation is reversible and dynamic in vivo, the phosphorylation state
of proteins is controlled by the opposing roles of protein tyrosine kinases (PTKs) and protein …

Adhesive structures between cells and with the surrounding matrix are essential for the
development of multicellular organisms. In addition to providing mechanical integrity, they …

Abstract Caveolin-1 (CAV1) has long been implicated in cancer progression, and while
widely accepted as an oncogenic protein, CAV1 also has tumor suppressor activity. CAV1 …

Background Non-receptor protein tyrosine phosphatases (PTPNs) are a set of enzymes
involved in the tyrosyl phosphorylation. The present study intended to clarify the …

Background: Elevated expression of CAV1 in breast cancer increases tumor progression.
Extracellular vesicles (EVs) from CAV1-expressing MDA-MB-231 breast cancer cells contain …

Gastric cancer is a high molecular heterogeneous disease with a poor prognosis. Although
gastric cancer is a hot area of medical research, the mechanism of gastric cancer …

In the brain, the role of matrilin-3, an extracellular matrix component in cartilage, is unknown.
Here, we identify that matrilin-3 decreased in reactive astrocytes but was unchanged in …

Simple Summary Caveolin-1 (CAV1) is a membrane protein that has been attributed a dual
role in cancer, acting at early stages as a tumor suppressor and in later stages of the …

Smooth muscle cell (SMC) phenotypic modulation, primarily driven by PDGFRβ signaling, is
implicated in occlusive cardiovascular diseases. However, the promotive and restrictive …

Caveolin-1 (CAV1) is a membrane-bound protein that suppresses tumor development yet
also promotes metastasis. E-cadherin is important in CAV1-dependent tumor suppression …