IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Leishmaniasis is a zoonotic and vector-borne infectious disease that is caused by the genus
Leishmania belonging to the trypanosomatid family. The protozoan parasite has a digenetic …

A key point of immunity against protozoan Leishmania parasites is the development of an
optimal T cell response, which includes a low apoptotic rate, high proliferative activity and …

Understanding the immune response to Leishmania infection and identifying biomarkers
that correlate with protection are crucial for developing effective vaccines. One intriguing …

Introduction In VL, a proinflammatory phenotype is typically associated with enhanced
phagocytosis and a Th1 mediated immune response resulting in infection control. In …

NK cells are known as frontline responders that are efficient in combating several maladies
as well as leishmaniasis caused by Leishmania spp. As such they are being investigated to …

Little is known about the immune response of lizards to Leishmania parasties. In this study,
we conducted the first liver transcriptome analysis of two lizards (Phrynocephalus …

Leishmaniasis, caused by obligate intracellular Leishmania parasites, poses a significant
global 19 health burden. The control of Leishmania infection relies on an effective T cell …

Tegumentary leishmaniasis (TL) is the main clinical manifestation of leishmaniasis, and it
can cause the infected hosts to self-healing cutaneous lesions until mutilating scars in …

Abstract Interleukin 35 (IL-35) mediates immunosuppression of T cells in autoimmune
diseases. T cells play an important role in primary biliary cholangitis (PBC) with incompletely …