Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of
people worldwide. However recent studies have indicated that niclosamide may have broad …

The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes
underlying the development and maintenance of adult tissue homeostasis, including …

Emerging evidence indicates that various cancers can gain resistance to targeted therapies
by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations …

The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the
lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC) …

Vaccines have reduced the transmission and severity of COVID‐19, but there remains a
paucity of efficacious treatment for drug‐resistant strains and more susceptible individuals …

While there are myriad mechanisms of primary and acquired resistance to conventional and
next-generation hormonal therapies in prostate cancer, the potential role of androgen …

Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …

Background Niclosamide, an FDA-approved anti-helminthic drug, has activity in preclinical
models of castration-resistant prostate cancer (CRPC). Potential mechanisms of action …

One of the leading causes of death worldwide, in both men and women, is cancer. Despite
the significant development in therapeutic strategies, the inevitable emergence of drug …

Prostate cancer (PC) remains a leading cause of cancer-related deaths among men
worldwide, despite continuously improved treatment strategies. Patients with metastatic …