The cannabinoid receptor type 2 (CB2) is a class A GPCR that was cloned in 1993 while
looking for an alternative receptor that could explain the pharmacological properties of Δ9 …

Recent studies have elucidated the biosynthetic pathway of cannabinoids and have
highlighted the preference for a C-3 n-pentyl side chain in the most prominently represented …

The cannabinoids are members of a deceptively simple class of terpenophenolic secondary
metabolites isolated from Cannabis sativa highlighted by (-)-Δ-tetrahydrocannabinol (THC) …

The identification of the CB2 cannabinoid receptor has provided a novel target for the
development of therapeutically useful cannabinergic molecules. We have synthesized …

Cannabinoids produce most of their biochemical and pharmacological effects by interacting
with CB1 and CB2 cannabinoid receptors, both of which are G-protein coupled membrane …

A novel series of dihydronaphthalene and benzosuberene analogs bearing structural
similarity to the combretastatins in terms of 1, 2-diarylethene, trimethoxyphenyl, and biaryl …

The cannabinoid CB1 and CB2 receptors belong to the Class A, rhodopsin-like family of G
protein-coupled receptors. Antagonists for each receptor sub-type, as well as four structural …

Structure− activity relationship studies have established that the aliphatic side chain plays a
pivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids. We …

Over the past 40 years, much research has been carried out directed toward the
characterization of the cannabinergic system. With the identification of two G-protein coupled …

1′, 1′-Cyclopropyl side chain substituents enhance the affinities of Δ8-
tetrahydrocannabinol and respective cannabidiol analogues for the CB1 and CB2 …