Patterns are ubiquitous in living systems and underlie the dynamic organization of cells,
tissues, and embryos. Mathematical frameworks have been devised to account for the self …

Apical constriction is a cell shape change that promotes tissue remodeling in a variety of
homeostatic and developmental contexts, including gastrulation in many organisms and …

INTRODUCTION The chromosome breakage-fusion-bridge (BFB) cycle is a catastrophic
mutational process, common during tumorigenesis, that results in gene amplification and …

Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …

One-cell-thick monolayers are the simplest tissues in multicellular organisms, yet they fulfill
critical roles in development and normal physiology. In early development, embryonic …

Mechanical forces direct a host of cellular and tissue processes. Although much emphasis
has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless …

Human carcinomas are comprised of complex mixtures of tumor cells that are known to
compete indirectly for nutrients and growth factors. Whether tumor cells could also compete …

Primitive streak formation in the chick embryo involves large-scale highly coordinated flows
of more than 100,000 cells in the epiblast. These large-scale tissue flows and deformations …

Cells adopt distinct signaling pathways to optimize cell locomotion in different physical
microenvironments. However, the underlying mechanism that enables cells to sense and …

Understanding how molecular dynamics leads to cellular behaviours that ultimately sculpt
organs and tissues is a major challenge not only in basic developmental biology but also in …