Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive
cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with …

Wnt signal cascade is an evolutionarily conserved, developmental pathway that regulates
embryogenesis, injury repair, and pathogenesis of human diseases. It is well established …

Wnt signalling is a complex, highly conserved, cell‐to‐cell communication pathway in
multicellular organisms, regulating cell fate, function and phenotype in development, and …

The mechanisms of tissue convergence and extension (CE) driving axial elongation in
mammalian embryos, and in particular, the cellular behaviors underlying CE in the epithelial …

Understanding how and when the left–right (LR) axis is first established is a fundamental
question in developmental biology. A popular model is that the LR axis is established …

Planar cell polarity (PCP), a process controlling coordinated, uniformly polarized cellular
behaviors in a field of cells, has been identified to be critically required for many …

During lung development, proper epithelial cell arrangements are critical for the formation of
an arborized network of tubes. Each tube requires a lumen, the diameter of which must be …

Cystic kidney diseases can cause end stage renal disease, affecting millions of individuals
worldwide. They may arise early or later in life, are characterized by a spectrum of symptoms …

Cell polarity refers to the orientation of tissue and organelles within a cell and the direction of
its function. It is one of the most critical characteristics of metazoans. The development …

Active Cdc42 GTPase, a key regulator of cell polarity, displays oscillatory dynamics that are
anticorrelated at the two cell tips in fission yeast. Anticorrelation suggests competition for …