Developments in vaccination for herpes simplex virus

R Krishnan, PM Stuart - Frontiers in microbiology, 2021 - frontiersin.org
Herpes simplex virus (HSV) is an alpha herpes virus, with two subtypes: HSV-1 and HSV-2.
HSV is one of the most prevalent sexually transmitted infections. It is the cause of severe …

An insight into current treatment strategies, their limitations, and ongoing developments in vaccine technologies against herpes simplex infections

D Sharma, S Sharma, N Akojwar, A Dondulkar… - Vaccines, 2023 - mdpi.com
Herpes simplex virus (HSV) infection, the most prevalent viral infection that typically lasts for
a lifetime, is associated with frequent outbreaks of oral and genital lesions. Oral herpes …

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection

KP Egan, LM Hook, A Naughton, N Pardi… - PLoS …, 2020 - journals.plos.org
HSV-1 causes 50% of first-time genital herpes infections in resource-rich countries and
affects 190 million people worldwide. A prophylactic herpes vaccine is needed to protect …

Bacterial-derived outer membrane vesicles are potent adjuvants that drive humoral and cellular immune responses

JT Prior, C Davitt, J Kurtz, P Gellings, JB McLachlan… - Pharmaceutics, 2021 - mdpi.com
Discovery and development of novel adjuvants that can improve existing or next generation
vaccine platforms have received considerable interest in recent years. In particular …

Small animal models to study herpes simplex virus infections

MT Hussain, BA Stanfield, DI Bernstein - Viruses, 2024 - mdpi.com
Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) are two of the
most prevalent human viruses worldwide. They are known to cause a variety of diseases …

Current vaccine approaches and emerging strategies against herpes simplex virus (HSV)

VN Wijesinghe, IA Farouk, NZ Zabidi… - Expert Review of …, 2021 - Taylor & Francis
Introduction Vaccine development for the disease caused by the herpes simplex virus (HSV)
has been challenging over the years and is always in dire need of novel approaches for …

Vaccines against genital herpes: Where are we?

HC Kim, HK Lee - Vaccines, 2020 - mdpi.com
Genital herpes is a venereal disease caused by herpes simplex virus (HSV). Although HSV
symptoms can be reduced with antiviral drugs, there is no cure. Moreover, because HSV …

Advances in alpha herpes viruses vaccines for human

M Preda, LSC Manolescu, RD Chivu - Vaccines, 2023 - mdpi.com
Alpha herpes simplex viruses are an important public health problem affecting all age
groups. It can produce from common cold sores and chicken pox to severe conditions like …

[HTML][HTML] Immunological Considerations for the Development of an Effective Herpes Vaccine

M Singer, MI Husseiny - Microorganisms, 2024 - mdpi.com
Research is underway to develop a vaccine to prevent and cure infection from herpes
simplex virus (HSV). It emphasizes the critical need for immunization to address public …

An Algorithm for the Development of a Recombinant Antiherpetic Subunit Vaccine Combining the Crystal Structure Analysis, AlphaFold2-Based Modeling, and …

TV Rakitina, EV Smirnova, DD Podshivalov… - Crystals, 2023 - mdpi.com
Using the envelope glycoprotein B (gB) crystal structure and digital prediction algorithm, the
B-and T-cell antigenic determinants (epitopes) of human herpesvirus 1 (HHV-1), also known …