CD39/CD73/A2AR pathway and cancer immunotherapy
C Xia, S Yin, KKW To, L Fu - Molecular cancer, 2023 - Springer
Cancer development is closely associated with immunosuppressive tumor
microenvironment (TME) that attenuates antitumor immune responses and promotes tumor …
microenvironment (TME) that attenuates antitumor immune responses and promotes tumor …
EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Antitumour immunity regulated by aberrant ERBB family signalling
S Kumagai, S Koyama, H Nishikawa - Nature Reviews Cancer, 2021 - nature.com
Aberrant signalling of ERBB family members plays an important role in tumorigenesis and in
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …
EGFR-mutated non-small cell lung cancer and resistance to immunotherapy: role of the tumor microenvironment
C Madeddu, C Donisi, N Liscia, E Lai… - International Journal of …, 2022 - mdpi.com
Lung cancer is a leading cause of cancer-related deaths worldwide. About 10–30% of
patients with non-small cell lung cancer (NSCLC) harbor mutations of the EGFR gene. The …
patients with non-small cell lung cancer (NSCLC) harbor mutations of the EGFR gene. The …
Exosome-based nanomedicine for cancer treatment by targeting inflammatory pathways: current status and future perspectives
MA Ansari, M Thiruvengadam, B Venkidasamy… - Seminars in cancer …, 2022 - Elsevier
Cancer is one of the dreadful diseases worldwide. Surgery, radiation and chemotherapy, are
the three basic standard modes of cancer treatment. However, difficulties in cancer treatment …
the three basic standard modes of cancer treatment. However, difficulties in cancer treatment …
Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma
How the glioma immune microenvironment fosters tumorigenesis remains incompletely
defined. Here, we use single-cell RNA-sequencing and multiplexed tissue-imaging to …
defined. Here, we use single-cell RNA-sequencing and multiplexed tissue-imaging to …
Recent developments and challenges in molecular-targeted therapy of non-small-cell lung cancer
Treatment of lung cancer with conventional therapies, which include radiation, surgery, and
chemotherapy results in multiple undesirable adverse or side effects. The major clinical …
chemotherapy results in multiple undesirable adverse or side effects. The major clinical …
Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non …
AA Chiappori, B Creelan, T Tanvetyanon, JE Gray… - Clinical Cancer …, 2022 - AACR
Purpose: The adenosine 2A receptor (A2AR) mediates the immunosuppressive effects of
adenosine in the tumor microenvironment and is highly expressed in non–small cell lung …
adenosine in the tumor microenvironment and is highly expressed in non–small cell lung …
Immune therapy resistance and immune escape of tumors
B Seliger, C Massa - Cancers, 2021 - mdpi.com
Simple Summary The genetic adaptability of malignant cells and their consequent
heterogeneity even within the same patient poses a great obstacle to cancer patient …
heterogeneity even within the same patient poses a great obstacle to cancer patient …
CD73, tumor plasticity and immune evasion in solid cancers
Simple Summary Tumors are ecosystems composed of cancer cells and non-tumor stroma
together in a hypoxic environment often described as wounds that do not heal. Accumulating …
together in a hypoxic environment often described as wounds that do not heal. Accumulating …