Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics

MJ Taylor, JK Lukowski… - Journal of the American …, 2021 - ACS Publications
Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Single‐cell mass spectrometry approaches to explore cellular heterogeneity

L Zhang, A Vertes - Angewandte Chemie International Edition, 2018 - Wiley Online Library
Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …

Sample preparation for mass spectrometry imaging: small mistakes can lead to big consequences

RJA Goodwin - Journal of proteomics, 2012 - Elsevier
Mass spectrometry imaging (MSI) enables the direct analysis of molecules from the surface
of a wide variety of samples, allowing the multiplex measurement of both abundance and …

Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS)

MK Passarelli, N Winograd - … et Biophysica Acta (BBA)-Molecular and Cell …, 2011 - Elsevier
Fundamental advances in secondary ion mass spectrometry (SIMS) now allow for the
examination and characterization of lipids directly from biological materials. The successful …

Profiling metabolites and peptides in single cells

SS Rubakhin, EV Romanova, P Nemes, JV Sweedler - Nature methods, 2011 - nature.com
The intracellular levels and spatial localizations of metabolites and peptides reflect the state
of a cell and its relationship to its surrounding environment. Moreover, the amounts and …

Deciphering metabolic heterogeneity by single-cell analysis

TMJ Evers, M Hochane, SJ Tans, RMA Heeren… - 2019 - ACS Publications
Single-cell analysis provides insights into cellular heterogeneity and dynamics of individual
cells. This Feature highlights recent developments in key analytical techniques suited for …

Lipid imaging by mass spectrometry–a review

D Gode, DA Volmer - Analyst, 2013 - pubs.rsc.org
Mass spectrometry imaging (MSI) has proven to be extremely useful for applications such as
the spatial analysis of peptides and proteins in biological tissue, the performance …

Advancements in ToF-SIMS imaging for life sciences

F Jia, X Zhao, Y Zhao - Frontiers in Chemistry, 2023 - frontiersin.org
In the last 2 decades, Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) has
gained significant prominence as a powerful imaging technique in the field of life sciences …

Mass spectrometry imaging and profiling of single cells

EJ Lanni, SS Rubakhin, JV Sweedler - Journal of proteomics, 2012 - Elsevier
Mass spectrometry imaging and profiling of individual cells and subcellular structures
provide unique analytical capabilities for biological and biomedical research, including …

Analytical challenges of microbial biofilms on medical devices

A Vertes, V Hitchins, KS Phillips - 2012 - ACS Publications
Analytical Challenges of Microbial Biofilms on Medical Devices | Analytical Chemistry ACS ACS
Publications C&EN CAS Find my institution Log In Analytical Chemistry ACS Publications. Most …