Thyroid hormones, oxidative stress, and inflammation

A Mancini, C Di Segni, S Raimondo… - Mediators of …, 2016 - Wiley Online Library
Inflammation and oxidative stress (OS) are closely related processes, as well exemplified in
obesity and cardiovascular diseases. OS is also related to hormonal derangement in a …

An organotypic atlas of human vascular cells

SN Barnett, AM Cujba, L Yang, AR Maceiras, S Li… - Nature Medicine, 2024 - nature.com
The human vascular system, comprising endothelial (EC) and mural cells, covers a vast
surface area in the body, providing a critical interface between blood and tissue …

Maternal hypothyroidism: An overview of current experimental models

M Ghanbari, A Ghasemi - Life sciences, 2017 - Elsevier
Maternal hypothyroidism (MH) is the most common cause of transient congenital
hypothyroidism. Different animal models are used for assessing developmental effects of …

Gut microbiota participates in antithyroid drug induced liver injury through the lipopolysaccharide related signaling pathway

J Sun, F Zhao, B Lin, J Feng, X Wu, Y Liu… - Frontiers in …, 2020 - frontiersin.org
Background: Drugs can alter the gut microbiota structure, and gut microbiota dysbiosis in
turn is correlated with drug side effects through the intestinal endotoxemia hypothesis …

Curdlan-Decorated Fullerenes Mitigate Immune-Mediated Hepatic Injury for Autoimmune Hepatitis Therapeutics via Reducing Macrophage Infiltration

C Fei, L Liu, H Qi, Y Peng, J Han… - ACS Applied Materials …, 2024 - ACS Publications
Autoimmune hepatitis (AIH) is a severe immune-mediated inflammatory liver disease whose
standard of care is immunosuppressive treatment with inevitable undesired outcomes …

Assessing the influence of propylthiouracil and phenytoin on the metabolomes of the thyroid, liver, and plasma in rats

Z Wang, SB Haange, V Haake, M Huisinga, H Kamp… - Metabolites, 2023 - mdpi.com
The thyroid hormones (THs) regulate various physiological mechanisms in mammals, such
as cellular metabolism, cell structure, and membrane transport. The therapeutic drugs …

Compensatory mechanisms in response to induced hypothyroidism in the late gestation pig fetus

EK Ison, CE Kent-Dennis, J Fazioli… - Biology of …, 2023 - academic.oup.com
To understand the effect of fetal thyroid gland disruption on development in swine, we
evaluated thyroid hormone levels, growth and developmental characteristics, and gene …

Nano‐selenium relieved hepatic and renal oxidative damage in hypothyroid rats

M Hosseini, F Behehsti, N Marefati… - Physiological …, 2023 - Wiley Online Library
Hypothyroidism can induce oxidative stress. Nano‐selenium (Nano Sel) has antioxidant
effects. The current research explored Nano Sel effects on hepatic and renal oxidative …

Protective effects of selenium on methimazole nephrotoxicity in adult rats and their offspring

IB Amara, A Troudi, E Garoui, A Hakim… - Experimental and …, 2011 - Elsevier
This study aims to investigate the improving effects of selenium on methimazole-induced
kidney impairments in adult rats and their pups. The animals were randomly divided into four …

[HTML][HTML] Methimazole-induced hypothyroidism causes alteration of the REDOX environment, oxidative stress, and hepatic damage; events not caused by …

E Cano-Europa, V Blas-Valdivia, GE Lopez-Galindo… - Annals of hepatology, 2010 - Elsevier
Our objective was to compare, over a time-course, markers of oxidative stress, the REDOX
environment, and the antioxidant enzymatic system in the liver of rats with methimazole-or …