This Perspective proposes definitions for key terms in the field of HIV-1 latency and
eradication. In the context of eradication, a reservoir is a cell type that allows persistence of …

Despite complete or near‐complete suppression of human immunodeficiency virus (HIV)
replication with combination antiretroviral therapy, both HIV and chronic …

In persons living with HIV-1 (PLWH) who start antiretroviral therapy (ART), plasma virus
decays in a biphasic fashion to below the detection limit. The first phase reflects the short …

The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …

Infection with HIV persists despite suppressive antiretroviral therapy (ART), and treatment
interruption results in rapid viral rebound. Antibody-mediated CD8+ lymphocyte depletion in …

Whether CD8+ T lymphocytes control human immunodeficiency virus infection by cytopathic
or non-cytopathic mechanisms is not fully understood. Multiple studies highlighted non …

Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to
below the limit of detection of clinical assays. However, even with prolonged suppression of …

In the absence of treatment, HIV-1 infection, usually starting with a single virion, leads
inexorably to a catastrophic decline in the numbers of CD4+ T cells and to AIDS …

An estimated 3% of the world's population is chronically infected with hepatitis C virus
(HCV). Although HCV was discovered more than 20 y ago, its origin remains obscure largely …

HIV is a disease in which the original clinical observations of severe opportunistic infections
gave the first clues regarding the underlying pathology, namely that HIV is essentially an …