Advances in structural identification of some thieno [2, 3-d] pyrimidine scaffolds as antitumor molecules: Synthetic approaches and control programmed cancer cell …
Abstract Thieno [2, 3-d] pyrimidine fragment is not only bioistostere to quinazoline ring but
also to purines which exist in nucleic acids responsible for several key biological processes …
also to purines which exist in nucleic acids responsible for several key biological processes …
Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study
Complications of the worldwide use of non-steroidal anti-inflammatory drugs (NSAIDs)
sparked scientists to design novel harmless alternatives as an urgent need. So, a unique …
sparked scientists to design novel harmless alternatives as an urgent need. So, a unique …
[HTML][HTML] Dual COX-2/TNF-α Inhibitors as Promising Anti-inflammatory and Cancer Chemopreventive Agents: A Review
M Tajdari, A Peyrovinasab, M Bayanati… - Iranian Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Cyclooxygenases (COX) play a pivotal role in inflammation and are responsible for the
production of prostaglandins (PGs). Two types of COXs have been identified as key …
production of prostaglandins (PGs). Two types of COXs have been identified as key …
New S‐substituted‐3‐phenyltetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidin‐4(3H)‐one scaffold with promising anticancer activity profile through the regulation and …
SE Seif, WW Wardakhan, RA Hassan… - Drug Development …, 2024 - Wiley Online Library
Abstract Novel 3‐phenyltetrahydrobenzo [4, 5] thieno [2, 3‐d] pyrimidine derivatives were
synthesized and screened for their antiproliferative activity against a panel of 60 cancer cell …
synthesized and screened for their antiproliferative activity against a panel of 60 cancer cell …
Design, synthesis and anti-inflammatory assessment of certain substituted 1, 2, 4-triazoles bearing tetrahydroisoquinoline scaffold as COX 1/2-inhibitors
MI Abo-Elmagd, RM Hassan, ME Aboutabl, KM Amin… - Bioorganic …, 2024 - Elsevier
Aiming to discover effective and safe non-steroidal anti-inflammatory agents, a new set of 1,
2, 4-triazole tetrahydroisoquinoline hybrids 9a-g, 11a-g and 12a-g was synthesized and …
2, 4-triazole tetrahydroisoquinoline hybrids 9a-g, 11a-g and 12a-g was synthesized and …
Antimicrobial Evaluation of Sulfonamides after Coupling with Thienopyrimidine Coplanar Structure
EI Elmongy, WS Alanazi, AI Aldawsari, AA Alfaouri… - Pharmaceuticals, 2024 - mdpi.com
This work describes the design and synthesis of three series of hybrids of thienopyrimidines
and sulfonamides. Dihydrofolate reductase enzyme was selected as a target for the in-silico …
and sulfonamides. Dihydrofolate reductase enzyme was selected as a target for the in-silico …
Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H 2 S release profiles
The development of H2S-donating derivatives of non-steroidal anti-inflammatory drugs
(NSAIDs) is considered important to reduce or overcome their gastrointestinal side effects …
(NSAIDs) is considered important to reduce or overcome their gastrointestinal side effects …
Anti-inflammatory Activity and Computational Biology Study of Indole/Pyrimidine Hybrids
This research paper embarks on an interdisciplinary exploration encompassing synthetic
chemistry, pharmacology, and computational biology. The development of novel anti …
chemistry, pharmacology, and computational biology. The development of novel anti …
[HTML][HTML] Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic …
X Fang, XF Jiang, YP Zhang, CL Zhou… - … Chemistry & High …, 2024 - ncbi.nlm.nih.gov
Aim: This study investigated the molecular action mechanism of a compound herb, also
known as the Dendrobium officinale throat-clearing formula (QYF), by using network …
known as the Dendrobium officinale throat-clearing formula (QYF), by using network …
REAÇÕES ADVERSAS DOS ANTAGONISTAS DA CICLOOXIGENASE–3 (COX–3): REVISÃO INTEGRATIVA
LN Mesquita, BP de Moraes, DC Miller… - … -ISSN 2675-6218, 2025 - recima21.com.br
Antecedentes: as reações adversas a medicamentos (RAM) que envolvem ação indireta
dos antagonistas da Ciclooxigenase–3 (COX–3) nas demais isoenzimas são pouco …
dos antagonistas da Ciclooxigenase–3 (COX–3) nas demais isoenzimas são pouco …