Although Alzheimer's disease is considered to be a degenerative brain disease, it is clear
that the immune system has an important role in the disease process. As discussed in this …

Amyloid-β and α-synuclein are intrinsically disordered proteins (IDPs), which are at the
center of Alzheimer's and Parkinson's disease pathologies, respectively. These IDPs are …

Passive immunization against β-amyloid (Aβ) has become an increasingly desirable
strategy as a therapeutic treatment for Alzheimer's disease (AD). However, traditional …

Immunotherapy for Alzheimer's disease (AD) relies on antibodies directed against toxic
amyloid-beta peptide (Aβ), which circulate in the bloodstream and remove Aβ from the …

Transgenic PDAPP mice, which express a disease-linked isoform of the human amyloid
precursor protein, exhibit CNS pathology that is similar to Alzheimer's disease. In an age …

Amyloid deposits within the cerebral tissue constitute a characteristic lesion associated with
Alzheimer disease. They mainly consist of the amyloid peptide Aβ and display an abnormal …

Plaques composed of amyloid β (Aβ) have been found within days following brain trauma in
humans, similar to the hallmark plaque pathology of Alzheimer's disease (AD). Here, we …

The epitope EFRH, corresponding to amino acids 3–6 within the human β-amyloid peptide
(AβP), acts as a regulatory site controlling both the formation and disaggregation process of …

Long-term vaccinations with human β-amyloid peptide 1-42 (A β 1-42) have recently been
shown to prevent or markedly reduce A β deposition in the PDAPP transgenic model of …

Cotton wool plaques (CWPs) are round lesions that lack a central amyloid core. CWPs have
been observed in individuals affected by early-onset familial Alzheimer disease (FAD) …