The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …

Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …

The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …

Estrogen affects proliferation and migration of different skin components, thus influencing
wound healing processes. The human keratinocyte cell line NCTC 2544 has been used to …

The hypothalamic–pituitary–thyroid axis plays a key role in skeletal development,
acquisition of peak bone mass and regulation of adult bone turnover. Euthyroid status is …

Thyroid hormones exert widespread and complex actions in almost all tissues during
development, throughout childhood and in adults. The skeleton is an important T3-target …

Thyroid hormone signaling is customized in a time and cell-specific manner by the
deiodinases, homodimeric thioredoxin fold containing selenoproteins. This ensures …

BACKGROUND: Thyroid hormones regulate skeletal development, acquisition of peak bone
mass and adult bone maintenance. Abnormal thyroid status during childhood disrupts bone …

Context: Thyroid function is known to play an important role in fetal neurological
development, but its role in regulating fetal growth is not well established. Overt maternal …

Metabolism of thyroid hormones by the type 2 and type 3 iodothyronine deiodinases (D2,
D3) in T3-responsive target cells is a sophisticated mechanism that helps to maintain local …