The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Glucose is the main energy substrate for the brain. There is now extensive evidence
indicating that the metabolic profile of neural cells with regard to glucose utilization and …

Over the past 2 decades there has been increasing evidence supporting an important
contribution from food-derived advanced glycation end products (AGEs) to the body pool of …

The formation and accumulation of advanced glycation endproducts (AGEs) are related to
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …

Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …

Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …

Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal-
physiological substrates of glyoxalase 1-iso potentially damaging to the proteome, genome …

Abnormal cellular accumulation of the dicarbonyl metabolite MG (methylglyoxal) occurs on
exposure to high glucose concentrations, inflammation, cell aging and senescence. It is …

Anxiety and fear are normal emotional responses to threatening situations. In human anxiety
disorders—such as panic disorder, obsessive–compulsive disorder, post-traumatic stress …

We review the transport, synthesis and catabolism of glutathione in the brain as well as its
compartmentation and biochemistry in different brain cells. The major reactions involving …