The major cardiac syndromes, myocardial infarction and heart failure, are responsible for a
large portion of deaths worldwide. Genetic and pharmacological manipulations indicate that …

Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its
cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in …

Gastric cancer remains the second leading cause of cancer deaths worldwide. Resistance to
chemotherapy is a significant barrier for effective cancer treatment. Here, we identified miR …

Abstract p53 plays an important role in regulating apoptosis. However, the molecular
mechanism by which it initiates the apoptotic program still remains to be fully understood …

Inactivation of the transcription factor p53 is central to carcinogenesis. Yet only
approximately one-half of cancers have p53 loss-of-function mutations. Here, we …

Multiple receptor tyrosine kinases (RTKs), including PDGFR, have been validated as
therapeutic targets in glioblastoma multiforme (GBM), yet inhibitors of RTKs have had limited …

Plant-based medicines are useful in the treatment of cancer. Many breast cancer patients
use complementary and alternative medicine in parallel with conventional treatments. Neem …

Identification of carcinogenic activity is the primary goal of the 2-year bioassay. The expense
of these studies limits the number of chemicals that can be studied and therefore chemicals …

One obstacle of cancer therapy is the development of cancer resistance to chemotherapy.
The molecular mechanisms by which the resistance is developed remain to be fully …

Apoptosis is a tightly regulated physiologic process of programmed cell death that occurs in
both normal and pathologic tissues. Numerous in vitro or in vivo studies have indicated that …