HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Increased sympathetic nervous system (SNS) activity has been associated with stress, major
depression, aging, and several medical conditions. This study assessed the effect of the …

5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or
neurotransmitter of several nervous system functions. Its actions are complex, and depend …

Diabetes and derived complications, especially diabetic nephropathy and neuropathy
annually cause great morbimortality worldwide. 5-hydroxytryptamine (5-HT) acts as a …

HT inhibits cardiac sympathetic neurotransmission in normoglycaemic rats, via 5-HT1B, 5-
HT1D and 5-HT5A receptor activation. Since type 1 diabetes impairs the cardiac …

This study aimed to investigate whether the 5-HT 2 receptor blockade alters the 5-HT effect
on vascular sympathetic neurotransmission and platelet activation in type 1 diabetes. 28-day …

We tested the hypothesis that the 5HT1DR, the primary antinociceptive target of triptans, is
differentially distributed in tissues responsible for migraine pain. The density of 5HT1DR was …

Introduction The pathologic mechanisms of primary premature ejaculation (PPE) are
complex and multifactorial, and hyperactivity of the sympathetic nervous system is one of the …

Background and Purpose In male rats, the serotonergic system modulates sympathetic
outflow at vascular levels, causing sympatho‐inhibition and sympatho‐excitation, mainly via …

Aims This study investigated whether fluoxetine treatment changes the 5-HT regulation on
vascular sympathetic neurotransmission in type 1 diabetes. Main methods Four-week …