Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

Clinical–pathological studies remain the gold‐standard for the diagnosis of Parkinson's
disease (PD). However, mounting data from genetic PD autopsies challenge the diagnosis …

The past decade has seen a dramatic expansion of the field of prodromal PD. Ten years
ago, there were only six known prodromal markers of disease, none of which had more than …

Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by
autonomic failure and motor impairment. The hallmark pathologic finding in MSA is …

Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Parkinson's disease (PD) is defined as a complex disorder with multifactorial pathogenesis,
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …

Over the past decades, tremendous progress has been made in the field of Gaucher
disease, the inherited deficiency of the lysosomal enzyme glucocerebrosidase. Many of the …

In recent years, multiple lines of evidence from human genetic and molecular studies have
highlighted the importance of the autophagy lysosomal pathway (ALP) in Parkinson's …

Purpose of Review GBA mutations are the most common known genetic cause of
Parkinson's disease (PD). Its biological pathway may be important in idiopathic PD, since …

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder characterized
by a variable combination of parkinsonism, cerebellar impairment, and autonomic …