Globally, esophageal cancer (EC) is the 6th leading cause of cancer-related deaths and the
second deadliest gastrointestinal cancer. Multiple genetic and epigenetic factors, such as …

Tumors develop multiple mechanisms of immune evasion as they progress, with some
cancer types being inherently better at 'hiding'than others. With an increased understanding …

Purpose The frequency of BRCA1 and BRCA2 germ-line mutations in women with ovarian
cancer is unclear; reports vary from 3% to 27%. The impact of germ-line mutation on …

Abstract Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) acts as a DNA damage sensor. It
recognizes DNA damage and facilitates DNA repair by recruiting DNA repair machinery to …

Poly (ADP-ribose) polymerase (PARP) inhibitors have shown promising activity in epithelial
ovarian cancers, especially relapsed platinum-sensitive high-grade serous disease …

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors cause targeted tumour cell death
in homologous recombination (HR)-deficient cancers, including BRCA-mutated tumours, by …

In this study, we investigated the effects of hesperidin (HSP) on oxidants/antioxidants status,
inflammation, apoptotic, and autophagic activity in hepato‐renal toxicity induced by chronic …

Poly-ADP-ribose metabolism plays a mayor role in a wide range of biological processes,
such as maintenance of genomic stability, transcriptional regulation, energy metabolism and …

Background Triple-negative breast cancers (TNBC) neither express hormone receptors, nor
overexpress HER2. They are associated with poor prognosis, as defined by low five-year …