Metabolic regulation plays important roles in embryo development and uterine receptivity
during early pregnancy, ultimately influencing pregnancy efficiency in mammals. The …

Prostaglandins are bioactive lipids that exert an autocrine or paracrine function by binding to
specific G-protein-coupled receptors (GPCRs) to activate intracellular signalling and gene …

Mechanosensing bone osteocytes express large amounts of connexin (Cx) 43, the
component of gap junctions; yet, gap junctions are only active at the small tips of their …

The corpus luteum (CL) is a transient ovarian endocrine gland formed from the ovulated
follicle. Progesterone is the primary secretory product of CL and is essential for …

Recognition and establishment of pregnancy involve several molecular and cellular
interactions among the conceptus, uterus, and corpus luteum (CL). In ruminants, interferon-τ …

The immune response of the CNS is a defense mechanism activated upon injury to initiate
repair mechanisms while chronic over-activation of the CNS immune system (termed …

Prostaglandins are primary mediators of pain and are involved in pathological conditions
such as hypertension, cancer and inflammation but are also needed for normal function of …

Solute carrier organic anion transporter family member 2A1 (SLCO2A1, also known as PGT,
OATP2A1, PHOAR2, or SLC21A2) is a plasma membrane transporter consisting of 12 …

The establishment of pregnancy is a complex process that requires a well-coordinated
interaction between the implanting conceptus and the maternal uterus. In pigs, the …

In ruminants, the corpus luteum (CL) of early pregnancy is resistant to luteolysis.
Prostaglandin (PG) E 2 is considered a luteoprotective mediator. Early studies indicate that …