Advances in drug delivery systems based on red blood cells and their membrane-derived nanoparticles

PHD Nguyen, MK Jayasinghe, AH Le, B Peng… - ACS nano, 2023 - ACS Publications
Red blood cells (RBCs) and RBC membrane-derived nanoparticles have been historically
developed as bioinspired drug delivery systems to combat the issues of premature …

Digging the intercellular crosstalkviaextracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?

A Macedo-Pereira, C Martins, J Lima… - … Clinics and Research, 2023 - journals.lww.com
Glioblastoma (GBM) is an adult's most aggressive brain tumor. The advances in molecular
pathology and cell signaling pathways have deepened researchers' understanding of …

[HTML][HTML] Endosomal escape of nucleic acids from extracellular vesicles mediates functional therapeutic delivery

TT Pham, H Chen, PHD Nguyen, MK Jayasinghe… - Pharmacological …, 2023 - Elsevier
Extracellular vesicles hold great promise as a drug delivery platform for RNA-based
therapeutics. However, there is a lack of experimental evidence for the intracellular …

Insight into the Functional Dynamics and Challenges of Exosomes in Pharmaceutical Innovation and Precision Medicine

A Sharma, A Yadav, A Nandy, S Ghatak - Pharmaceutics, 2024 - mdpi.com
Of all the numerous nanosized extracellular vesicles released by a cell, the endosomal-
originated exosomes are increasingly recognized as potential therapeutics, owing to their …

[HTML][HTML] On the interaction and nanoplasmonics of gold nanoparticles and lipoproteins

A Zendrini, J Cardellini, R Frigerio, M Bertoni, D Berti… - JCIS Open, 2023 - Elsevier
The extracellular space is nanostructured, populated by heterogeneous classes of
nanoparticles, eg, extracellular vesicles and lipoproteins, which “made by cells for …

Systematic review and bioinformatics analysis of plasma and serum extracellular vesicles proteome in type 2 diabetes

JG Arredondo-Damián, JM Martínez-Soto… - Heliyon, 2024 - cell.com
Abstract Background Type 2 diabetes (T2D) is a complex metabolic ailment marked by a
global high prevalence and significant attention in primary healthcare settings due to its …

A pH-Mediated Highly Selective System Enabling Simultaneous Analysis of Circulating RNAs Carried by Extracellular Vesicles and Lipoproteins

R Yang, D Lou, K Xia, L Sun, Q Zhu - Analytical Chemistry, 2023 - ACS Publications
Extracellular vesicles (EVs) and lipoproteins (LPPs) serve as important carriers of circulating
miRNAs in peripheral blood, offering immense potential for disease diagnosis and …

Human Plasma-Derived Exosomes: A Promising Carrier System for the Delivery of Hydroxyurea to Combat Breast Cancer

W Khalid, A Aslam, N Ahmed, M Sarfraz, JA Khan… - AAPS …, 2025 - Springer
The aim of the present study was to investigate the potential of human plasma derived
exosomes for the delivery of hydroxyurea to enhance its therapeutic efficacy in breast …

Attempts to preserve and visualize protein corona on the surface of biological nanoparticles in blood serum using photomodification

JE Poletaeva, AV Tupitsyna… - Beilstein Journal of …, 2024 - beilstein-journals.org
A protein corona is present on any nanoparticle (NP) entering biological fluids; however, the
existence of a natural protein corona on natural NPs has not been experimentally confirmed …

Comparison of serum levels of IL-10 and IL-11 and mRNA expression of IL-10, IL-11, COX-2, BCL6, and ZEB Family in peripheral blood mononuclear cells (PBMC) of …

M Nikseresht, AM Shahrebabaki… - Journal of Reproductive …, 2024 - Elsevier
Background The roles of IL-10, IL-11, COX-2, BCL6, ZEB1, and ZEB2 genes in the potential
correlation between polycystic ovary syndrome (PCOS), inflammation, and cancer remain …