Sepsis, a dysregulated immune response due to life-threatening organ dysfunction, caused
by drug-resistant pathogens, is a major global health threat contributing to high disease …

Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect
drug pharmacokinetics and pharmacodynamics making dose optimisation particularly …

Sepsis is one of the leading causes of death worldwide with high mortality rates and a
pathological complexity hindering early and accurate diagnosis. Today, laboratory culture …

The pathophysiology of sepsis alters drug pharmacokinetics, resulting in inadequate drug
exposure and target-site concentration. Suboptimal exposure leads to treatment failure and …

Treatment failure of antibiotic therapy due to insufficient efficacy or occurrence of toxicity is a
major clinical challenge, and is expected to become even more urgent with the global rise of …

Abstract Sepsis-Associated Acute Kidney Injury is a life-threatening condition leading to high
morbidity and mortality in critically ill patients admitted to the intensive care unit. Over the …

Sepsis is a life-threatening response to infection that contributes significantly to neonatal
and pediatric morbidity and mortality worldwide. The key tenets of care include early …

Extracorporeal membrane oxygenation (ECMO) is an emerging treatment modality
associated with a high frequency of antibiotic use. However, several covariables emerge …

Sepsis is a leading cause of disability and mortality worldwide. The pathophysiology of
sepsis relies on the maladaptive host response to pathogens that fosters unbalanced organ …

While early and precise diagnosis is the key to eliminating tuberculosis (TB), conventional
methods using culture conversion or sputum smear microscopy have failed to meet demand …