Leishmaniasis is a group of infectious neglected tropical diseases caused by more than 20
pathogenic species of Leishmania sp. Due to the limitations of the current treatments …

Antimicrobial resistance (AMR) threatens the prevention and treatment of infections caused
by a large range of microorganisms. Leishmania is not an exception and treatment failure …

The high potential of quinoline containing natural products and their derivatives in medicinal
chemistry led us to discover novel series of 25 compounds for the development of new …

Background There is a pressing need for drug discovery against visceral leishmaniasis, a
life-threatening protozoal infection, as the available chemotherapy is antiquated and not …

Leishmaniasis and Chagas disease are endemic pathologies in tropical countries. These
cause high morbidity and a public health problem. Current chemotherapies are based on …

Cancer is a common disease that poses a serious threat to human health. Angiogenesis is
essential for the growth and metabolism of tumors, providing oxygen and nutrition for the …

A series of new phenoxyacetophenone hydrazones 6a-l bearing a 4-arylthiazole moiety
were synthesized and tested as antileishmanial agents. After spectroscopic and …

Abstract Changes in host immunity and parasite resistance to drugs are among the factors
that contribute to decreased efficacy of antiparasitic drugs such as the antimonial …

New drugs for the treatment of human leishmaniasis are urgently needed, considering the
limitations of current available options. However, pre-clinical evaluation of drug candidates …

Protozoan parasites of the genus Leishmania are responsible for leishmaniases, one of the
most important anthropozoonotic diseases affecting millions of people worldwide. To date …