Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and
survival while subject to changes in environmental cues. Thus, a vital component of a cancer …

Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Malignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer
characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable …

Diabetic retinopathy remains the major cause of blindness among working age adults.
Although a number of metabolic abnormalities have been associated with its development …

Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer
cells. Exosomes are secreted nanovesicles that have key roles in cell–cell communication …

Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …

Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer
progression. Tumour induced beige/brown adipose tissue differentiation contributes to the …

Background—Right ventricular (RV) failure is the most important factor of both morbidity and
mortality in pulmonary arterial hypertension (PAH). However, the underlying mechanisms …

Obesity is a multifactorial and complex condition that is characterized by abnormal and
excessive white adipose tissue accumulation, which can lead to the development of …

Lung cancer is one of the leading causes of cancer-related deaths. It is diagnosed mostly at
the locally advanced or metastatic stage. Recently, micro RNAs (miRs) and their distribution …