Tramadol is a unique analgesic medication, available in variety of formulations, with both
monoaminergic reuptake inhibitory and opioid receptor agonist activity increasingly …

In vitro pharmacological profiling is increasingly being used earlier in the drug discovery
process to identify undesirable off-target activity profiles that could hinder or halt the …

The serotonin syndrome is a medication-induced condition resulting from serotonergic
hyperactivity, usually involving antidepressant medications. As the number of patients …

Objective The use of opioids to treat chronic pain has come under increased scrutiny, as
such use has been associated with significant risk of death, with limited data regarding the …

5-Methoxy-N, N-dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring
psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and …

Methylene blue has only recently been noted to cause severe central nervous system
toxicity. Methylene blue is used for various conditions, including, intravenously, in …

Background Serotonin syndrome is a toxic state, caused by serotonin (5HT) excess in the
central nervous system. Serotonin syndrome's main feature is neuro-muscular …

The use of several new psychoactive substances (NPS) has become very popular and is
posing global health risks. Chemically and pharmacologically diverse molecules are …

Importance of the field: Selective serotonin reuptake inhibitors (SSRIs) and serotonin
noradrenaline reuptake inhibitors (SNRIs) are becoming increasingly used in the treatment …

The serotonin syndrome (SS) is a potentially life-threatening disorder in humans which is
induced by ingestion of an overdose or by combination of two or more serotonin (5-HT) …